Modulation of cancer therapy using nano-organometallic compounds: preparation, spectroscopic characterization and cytotoxic evaluation.

New series of Mn(II), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) organometallic complexes with hydroxyl benzylidene malonohydrazide ligand have much potential as therapeutic diagnostic agents. The allows the thermodynamic kinetic reactivity metal ion to be controlled also provide a scaffold for functionalization. establishment structure activity relationships elucidation specification under conditions relevant drug testing formulation are crucial further development promising medicinal applications complexes. Specific examples involving design anticancer agents discussed. These been synthesized characterized by (1H-NMR, mass, IR, UV-VIS ESR) spectroscopy, well magnetic moments, conductance, elemental thermal analyses. Molar conductance in DMF solution indicates that, non-electrolytes. ESR spectra solid Cu(II) (7) (8) showed isotropic anisotropic types indicating an octahedral geometry covalent bond character. However, Co(II) (3) (4) type where, g┴ > g|| >2.0023, compressed tetragonal distortion around ion. Cytotoxic evolution its carried out. Complexes enhanced comparison parent or standard applied.